A transporter lorry carrying eight brand new vehicles has overturned on the A15 near Scampton.
The incident, which was reported at 10.30am, saw one Volvo car fly from the back of the lorry while all others remained fixed.
Lincolnshire Police confirmed there were no injuries at the scene.
The A15 will be closed northbound from the Lincolnshire Showground to Caenby Corner for two hours from 1:30pm while police attempt to recover the vehicles involved.
Police said that a heavy duty recovery operation will be needed to rotate the lorry, and further delays may be incurred.