Emergency services have been called to a collision involving two cars on Tritton Road.
The incident happened at around 10.53am on Wednesday, September 28 on Tritton Road near the LN6 development.
The incident happened at around 10.53am this morning.
One man has been taken to hospital and Lincolnshire Fire and Rescue are on scene to help release a woman from the other vehicle. She is thought to have life changing injuries.
The road is currently closed from Dixon Street to Skellingthorpe Road.
It is unknown when the road will reopen.
Police are advising road users to use alternative routes.
Police are asking that anyone with any information about the accident should call 101 quoting incident number 128 of September 28.
Update: The road has now reopened
Tritton Road, Lincoln is now open after the serious RTC. However Skellingthorpe Road rail barriers are stuck in the down position.
— EMOpSS RAPT Lincs (@LincsRAPT) September 28, 2016