Road resurfacing works on the B1202 at Nocton will begin on Monday for one week.
The road will be closed to traffic for the duration of the repairs scheme.
Work is expected to be completed by March 12 (subject to weather conditions).
Traffic will be diverted along the B1188 via Branston to Canwick Hill, Lincoln, and onto the B1190 Washingborough Road, Lincoln, to Potterhanworth Booths.
High-sided vehicles will be able to avoid the low bridge on Station Road in Potterhanworth.
Local bus routes will be affected by the closure, so people should contact their relevant bus company for further information.
A highways spokesperson from Lincolnshire County Council said: “There is a section of road from the north of Nocton Park Road to the north of Nocton Fen Lane that has seen better days so we’re going in to repair it.
“During the closure, our gritters won’t be able to treat this section of road, so people will need to take extra care during bad weather.”