Washingborough Road will be closed for two weeks as part of the Lincoln Eastern Bypass project.
The closure will allow ducting works around the perimeter of the proposed Washingborough Road roundabout.
Works on Washingborough Road will take place from 6am on Monday, October 29 to 6pm on Sunday, November 11.
Councillor Richard Davies, executive member for highways at Lincolnshire County Council, said: “This is one of the first steps towards building the new Washingborough Road roundabout – one of four new roundabouts being constructed as part of the Lincoln Eastern Bypass.
“Because these works will require us to install ducting across Washingborough Road, a full road closure will be in place for two weeks starting later this month.
“In addition to the signed diversion route that will be in place, we’ll do everything else we can to minimise disruption and ensure these works go as smooth as possible.”
The diversion route for the closure will be via B1190 Washingborough Road, B1188 Lincoln Road, Station Road, Branston Road, Sheepwash Lane, Pitts Road, B1190 Washingborough Road and vice versa.
HGVs will be diverted via Nocton & Potterhanworth.
Councillor Davies added: “We want to thank everyone for bearing with us during this and all other works part of building the Lincoln Eastern Bypass.
“We promise that any short-term disruption will be greatly outweighed by all the benefits that will come once the new road is opened in 2020.”
The 7.5km Lincoln Eastern Bypass project is part-funded by a £50m Central Government capital grant and will improve Lincoln’s infrastructure, encourage growth, minimise traffic congestion and enhance the inter-city environment.