Motorists are being advised to avoid the A46 from Nettleham towards Welton during six weeks of overnight road resurfacing works.
As part of the improvements, the work will be carried out overnight from 8pm to 6am on weekdays from Monday, February 4.
Diversion routes will be in place through the A46 Lincoln Road, Gallamore Lane, Caistor Road, A1103, A631 and A15.
Councillor Richard Davies, Executive Member for Highways, said: “As part of these improvements, we’ll be rebuilding a 2.5km section of the A46 to replace road surface that is nearing the end of its serviceable life.
“Due to the nature of the works, there will inevitably be some temporary disruptions. However, we’ll be doing everything we can to minimise these – including scheduling the works overnight to lessen the impact for road users.
“Also, every effort will be made to keep the noise level to a minimum after 11pm however, works will continue throughout the night.
“We ask for your continued patience while these works are carried out. Not only will the road’s life be extended, but these improvements will also ensure smoother journeys and increased safety for all road users.”