Lincolnshire County Council will close the A1500 Tillbridge Lane Sturton by Stow for 12 days in April for road repairs.
Worn-out sections of the carriageway are set to be repaired so the road can be surface dressed during the summer.
The £160,000 project is due to begin on Monday, April 1, and is expected to be completed by Friday, April 12.
The road will be closed for the duration of the project, with traffic diverted via the A156, A57, A46, A15 and A1500.
A highways spokesperson said: “This road is set to be surface dressed later this year, which will help extend its life.
“However, before we do that, we need to go in and repair any potholes or other defects.
“We apologise for any inconvenience caused and will aim to get the road re-opened as soon as possible.”