A part of the road between the Doddington Road traffic lights and Station Road junction in Lincoln will be closed for four weekends.
The closures are to allow for upgrade works worth £3.2 million on Whisby Road in North Hykeham.
The section from the Doddington Road traffic lights and Station Road junction will be closed from 8pm on Friday, February 28, to 6am on Monday, March 3.
The same part will be closed again between the same times from March 14 to 17, once more between March 28 and 31, and finally between Saturday, April 5, and Monday, April 7.
The diversion route is via Doddington Road, Tritton Road, Newark Road and Station Road (or the reverse as appropriate). The diversion route will be signed during the period of closure.
The works on Whisby Road started in October 2013, and are set to last 12 months.
A new traffic light system at the Whisby Road junction with Doddington Road will reduce motorists’ waiting times by up to 20%, Lincolnshire County Council says.
The work takes place from Doddington Road up to the roundabout with Teal Park and facilitates access to the A46, Energy from Waste site, Teal Park and Kingsley Road Business Park.
From the Whisby Road junction with Station Road through to the new Teal Park Roundabout, Whisby Road has been one-way westbound only since the start of the work.
When finalised, the improvements will include a wide road surface, a combined footpath and cyclepath on both sides of the road, low-energy LED street lights, a roundabout at the junction with Station Road.
There will also be two new toucan crossings near the Whisby Road junction with Station Road to allow pedestrians and cyclists to cross the road safely.