An air ambulance has been dispatched to a serious crash on the M180, with the motorway closed in both directions.
The single-vehicle crash happened on the westbound carriageway between junction 5 for Barnetby Top and junction 4 for Scawby.
Paramedics from East Midlands Ambulance Service and firefighters from Scunthorpe and Immingham are in attendance.
There are significant tailbacks and motorists should avoid the area.
A spokesperson for Humberside Police said: “A car left the road resulting in the driver suffering injuries.
“The extent of his injuries are yet to be established.”