A section of Canwick Road in Lincoln was closed in both directions after a crash between a lorry and a car at around 12.30pm on Thursday.
One man was injured in the crash and was taken to hospital, however his injuries are not believed to be serious.
Fire crews, paramedics and police officers were on scene to deal with the incident and clear the road.
Traffic was severely affected in the South Park area and public transport has been delayed on a number of routes as a result.
The road reopened fully at 2.17pm, Lincolnshire Police said.