Police are at the scene of a crash on the northbound carriageway of the A15 near Barton.
Humberside Police said the road is currently closed after the crash on Monday, February 25. It is expected to remain closed into the evening.
It is closed between the B1206 and A1077 to allow emergency services to carry out their work.
Humberside Police is advising drivers to avoid the area as their travel will be disrupted.
The extent of any injuries are not yet known. Humberside Police were contacted for further information, but there was no response by the time of publication.