Drivers faced lunchtime disruption on the A15 at Caenby Corner after a collision involving a tanker, which came off the road.
Lincolnshire Police said that while the road reopened at about 1pm, it would close again at around 2pm, for recovery of the vehicle.
The crash happened at around 12.10pm near Blyborough.
No injuries have been reported at the time of writing.
Police advise drivers to find alternative routes where possible.