The A1031 will be resurfaced between Church Lane and Firebeacon Lane at Eskham, Marshchapel next month.
Lincolnshire County Council has said the road surface has reached the end of its working life and needs replacing.
The works will take place from Monday, September 5 to Friday, September 30, and will take place overnight during weekdays, Monday to Friday (7pm-6am).
The road will be closed during those times, between Church Lane and Firebeacon Lane.
Diversion routes will be signed via the A1031 north, the B1201 west, A16 south, A157 east, B1200 east and A1031 north and vice versa.
Steve Brooks, senior project leader (major schemes) for Lincolnshire County Council, said, “The resurfacing works will prevent further deterioration to this section of road and ensure that it is safe and serviceable for many more years.
“The works have been scheduled to take place after school summer holidays as experience shows there is noticeably less traffic.
“We have taken the decision to work overnight to further reduce disruption to the road network.
“Access will be maintained for residents and businesses alike, although the road will be closed to through traffic to ensure the safety of the workforce and the public.”