A man has died after a crash on the A15 near Scampton at around 4.45pm on Monday.
Emergency services were called to the scene where a silver Mercedes articulated lorry crashed with a blue BMW.
The driver of the BMW, a man in his 30s from Lincoln, was airlifted to Hull Royal Infirmary but died later.
Police are seeking witnesses to the collision or anyone who saw either of the vehicles before the crash.
The road re-opened about 4am on Tuesday.
Anyone with any information is asked to contact 101 quoting incident 319 of May 21.