A stretch of the A18 in the north of the county has been named as one of the top 10 high risk roads in the whole of the country.
The road between the junction with the A46 near Laceby to the junction with the A16 near Ludborough was cited by the Road Safety Foundation as the most dangerous in Lincolnshire and one of the most hazardous in the UK.
The charity has urged the government to spend £200 million to tackle the most high risk roads in the country.
So far this year, the stretch of the A18 has claimed the lives of two people, with others being seriously injured.
Daniel Thomas, 31, from Healing near Grimsby, died at the scene of a two-vehicle crash near Ludborough on Wednesday, February 8.
Just over three months later, 45-year-old Grimsby man Alan Critchley, known affectionately as ‘Critch’, died in hospital after the motorbike he was riding was involved in a crash with a Renault Clio, again near Ludborough.
The popular biker was killed in the crash on Wednesday, May 31.
One month earlier, another biker in his 60s was seriously injured in a crash on the same stretch of road.
The A18 Binbrook to North Thoresby junction was closed, as well as the junction of Livesey Road and Lincoln Gate at Ludborough.
Just a couple of miles north on the A18, a 77-year-old man died at the scene of a three-vehicle crash near to the junction with Nooking Lane on Saturday, September 9.
A 49-year-old man, suffered serious but not life-threatening injuries, and the road was closed for over seven hours.
Further west, the A18 claimed the life of Scunthorpe biker Chris Gough, 51, on Sunday, January 8, following a crash between a grey Renault Megane and black BMW motorbike.
The seven mile stretch of the A537 between Buxton and Macclesfield, nicknamed locally the Cat and Fiddle, has been the most hazardous UK road six times out of the last 10 years.