The A46 between the Carholme and Riseholme roundabouts will be down to just one lane on either side for another three days.
A transporter lorry crashed into the central reservation, overturning and losing cars overnight on Wednesday, January 22 and the road was closed in both directions for around 20 hours.
The accident caused significant damage to the central reservation, and spread debris and fuel across both carriageways.
Crews have been on site since the early hours of Thursday morning removing debris, cleaning fuel off the road, and starting to dismantle the damaged barrier so it can be repaired.
Over 30m of the central reservation has been damaged in the accident and will need to be replaced, Lincolnshire County Council said. Due to the extent of the damage, this could take up to three days.
A single-lane closure in both directions will remain in force whilst work takes place on the barrier.
Councillor Richard Davies, the executive member for highways at the county council, said: “The safety of road users is our number one priority, and we would only ever close a road or a lane when it is absolutely necessary to keep drivers safe.
“We understand that the aftermath of this accident has caused major disruption in and around Lincoln, and we are sorry about the delays.”