Police and Fire and Rescue crews were called to a serious crash which closed Belton Road, Great Gonerby near Grantham overnight.
The collision, which happened just before midnight on Friday, February 4, involved two vehicles, a black Audi A3 and a blue Audi A4.
The collision happened on the bridge over the railway track.
Lincolnshire Fire and Rescue said crews used hydraulic cutting equipment to free one casualty.
Lincolnshire Police later confirmed that two people had been taken to Queen’s Medical Centre in Nottingham with serious injuries.
The road remained closed into the morning, while Highways services worked to clear the lane.
Lincolnshire Police posted on social media in the early hours of Saturday, February 4 to inform drivers the road was expected to be closed for several hours. People should avoid the area where possible.